Beilstein J. Org. Chem.2023,19, 231–244, doi:10.3762/bjoc.19.22
, metal-free and easy to perform reaction conditions. Moreover, the pyrazole C-3/5-linked amide conjugates were also synthesized via an oxidative amination of pyrazole carbaldehydes and 2-aminopyridines using hydrogen peroxide as an oxidant.
Keywords: C–S/Obondformation; metal-free; oxidative amidation
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Graphical Abstract
Figure 1:
Representative drug molecules based on pyrazole, thioamide, and amide derivatives.